Manufacturer
Distributor Contents Indications Dosage Administration Contraindications Special Precautions Adverse Drug Reactions Side Effects Drug Interaction Pregnancy Category (US FDA) Storage Mechanism of Action MIMS Class ATC Classification Regulatory Classification |
Pond's Chemical
DKT Lynestrenol OC. Also for lactating mothers & smoking women who require contraception. Contraception, especially in cases of intolerance from estrogen-progestogen combined pills or when estrogens are contraindicated. Daphne is also indicated in lactating mothers and smoking women who require contraception. 1 tab daily beginning on the 1st day of cycle. Start a new pack w/o any gap between cycles. If a tab is missed for <3 hr, take immediately. Continue w/ usual daily tab taking. May be taken with or without food Undiagnosed vag bleeding, severe arterial disease, hormone-dependent neoplasm, severe liver disease e.g. hepatic adenoma & after recurrent evacuation of a hydatidiform mole; porphyria. Pregnancy & lactation before the 6th wk postpartum. Women with undiagnosed vaginal bleeding, severe arterial disease, hormone dependent neoplasm, severe liver disease eg, hepatic adenoma and after recent evaculation of a hydatidiform mole. Daphne should not be given in women with porphyria. Severe diarrhea or vomiting & taking tab irregularly lessens reliability. Heart disease, malabsorption syndrome, liver dysfunction, functional ovarian cyst, DM, HTN, migraine, thromboembolic disorders, renal impairment, asthma, epilepsy, history of depression, other conditions which may be aggravated by fluid retention. May decrease glucose tolerance thus, diabetics should be monitored. History of jaundice in pregnancy, past ectopic pregnancy. GI disturbances, changes in appetite or wt, fluid retention, edema, chloasma, allergic skin rashes, urticaria, mental depression, breast changes, changes in libido, hair loss, hirsutism, fatigue, drowsiness or insomnia, fever, headache, premenstrual syndrome-like symptoms, alterations in the serum lipid profile. Some women may experience side effects eg, nausea, vomiting, headache, breast discomfort, depression, skin rashes and slight weight change. Menstrual irregularities eg, amenorrhea, breakthrough bleeding, spotting and menorrhagia are common with progestogen-only contraceptives. Most of these side effects are mild and usually disappear after a few months of contraceptive use. Women who are using Daphne have lesser risk for thromboembolic and cardiovascular disease than those using combined oral contraceptives Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). Store at a temperature not exceeding 30°C. Pharmacotherapeutic Group: Oral contraceptive. Daphne is a progestogen-only oral contraceptive pill. Progestogens are derived from the natural hormone progesterone or 19-nortestosterone, which actions are similar to those of progesterone. Daphne stops ovulation, thins the lining of the uterus and thickens the cervical mucus. In combination, these actions prevent pregnancy. Daphne is safe to use by breastfeeding mothers. Pharmacokinetics: Progesterone, like Daphne, has a short elimination t½ and undergoes extensive first-pass hepatic metabolism when taken orally. The oral bioavailability is very low but may be increased by an oily vehicle and micronization. Oral Contraceptives G03DC03 - lynestrenol ; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations. Rx |